تفاعل #2559

معادلة التفاعل

3-Methoxy-N-(2-methoxyphenyl)-N-(2-tetrahydropyranyloxyethyl)benzamide

p-toluenesulfonic acid monohydrate

sodium bicarbonate

→

title compound

المردود 86.8%

N-(2-Hydroxyethyl)-3-methoxy-N-(2-methoxyphenyl)benzamide

المردود 86.8%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ether
2. 2
   غسيلwashed with water and saturated brine
3. 3
   تجفيفThe resulting organic layer was dried on anhydrous magnesium sulfate
4. 4
   أخرىthe solvent was removed by evaporation
5. 5
   أخرىthe resulting colorless oily residue was purified

الإجراء التجريبي

3-Methoxy-N-(2-methoxyphenyl)-N-(2-tetrahydropyranyloxyethyl)benzamide (501 mg, 1.30 mmol) was dissolved in methanol (4 ml) to which was subsequently added a catalytically effective amount of p-toluenesulfonic acid monohydrate and stirred for 3 hours at room temperature. The reaction solution was mixed with saturated sodium bicarbonate aqueous solution (10 ml) and extracted with ether, and then washed with water and saturated brine. The resulting organic layer was dried on anhydrous magnesium sulfate, the solvent was removed by evaporation and then the resulting colorless oily residue was purified by subjecting it to a silica gel column chromatography (ether:hexane=3:1) to obtain 340 mg (86.8%) of the title compound in the form of light yellow oil.

المصدر