تفاعل #2556

معادلة التفاعل

4-(4-Fluorobenzoyl)piperidine

bromoacetoaldehyde diethylacetal

triethylamine

→

title compound

المردود 25.0%

1-(2,2-Diethoxyethyl)-4-(4-fluorobenzoyl)piperidine

المردود 25.0%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter 12 hours of heating
2. 2
   درجة الحرارةunder reflux
3. 3
   أخرىthe solvent was removed by evaporation
4. 4
   أخرىthe resulting residue was purified

الإجراء التجريبي

4-(4-Fluorobenzoyl)piperidine (207 mg, 1.0 mmol) was dissolved in methylene chloride (5 ml) to which were subsequently added bromoacetoaldehyde diethylacetal (305 mg, 1.5 mmol) and triethylamine (0.5 ml). After 12 hours of heating under reflux, the solvent was removed by evaporation, and the resulting residue was purified by subjecting it to a silica gel column chromatography (ether) to obtain 81 mg (25.0%) of the title compound in the form of orange oil.

المصدر