تفاعل #2553

معادلة التفاعل

4-(4-fluorobenzoyl)piperidine

2-bromoethanol

→

title compound

المردود 78.0%

4-(4-Fluorobenzoyl)-1-(2-hydroxyethyl)piperidine

المردود 78.0%

المذيبات

triethylamine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter 1 hour of heating
2. 2
   درجة الحرارةunder reflux
3. 3
   أخرىtriethylamine was removed by evaporation
4. 4
   workup.ADDITIONthe resulting residue was mixed with saturated sodium carbonate aqueous solution (40 ml)
5. 5
   استخلاصextracted with ethyl acetate
6. 6
   تجفيفThe resulting organic layer was dried on anhydrous sodium carbonate
7. 7
   أخرىthe solvent was removed by evaporation
8. 8
   أخرىthe resulting residue was purified

الإجراء التجريبي

In an atmosphere of argon, 4-(4-fluorobenzoyl)piperidine (2.07 g, 10 mmol) was dissolved in triethylamine (30 ml) to which was subsequently added dropwise 2-bromoethanol (1.1 ml, 14.7 mmol) at room temperature. After 1 hour of heating under reflux, triethylamine was removed by evaporation, and the resulting residue was mixed with saturated sodium carbonate aqueous solution (40 ml) and extracted with ethyl acetate. The resulting organic layer was dried on anhydrous sodium carbonate, the solvent was removed by evaporation and then the resulting residue was purified by subjecting it to a silica gel column chromatography (ethyl acetate-methylene chloride:methanol=10:1) to obtain 1.96 g (78.0%) of the title compound in the form of light yellow solid.

المصدر