تفاعل #2551

معادلة التفاعل

4-Chloromethyl-N-(2-methoxyphenyl)benzamide

methylamine

→

title compound

المردود 100.0%

N-(2-Methoxyphenyl)-4-(methylamino)methylbenzamide

المردود 100.0%

المذيبات

dioxane

dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىwas removed by evaporation
2. 2
   workup.ADDITIONthe resulting residue was diluted with methylene chloride (10 ml)
3. 3
   تجفيفAfter drying on anhydrous sodium carbonate
4. 4
   أخرىthe solvent was removed by evaporation

الإجراء التجريبي

4-Chloromethyl-N-(2-methoxyphenyl)benzamide (400 mg, 1.45 mmol) was dissolved in dioxane (4 ml) and then mixed with 50% methylamine aqueous solution (4 ml) at room temperature. After 1 hour of stirring at the same temperature, dioxane was removed by evaporation, and the resulting residue was diluted with methylene chloride (10 ml). After drying on anhydrous sodium carbonate, the solvent was removed by evaporation to obtain 500 mg (100%) of the title compound in the form of colorless oil.

المصدر