تفاعل #2507829

معادلة التفاعل

6-fluoro-3-pentylchroman-7-carbaldehyde

sodium borohydride

→

(6-fluoro-3-pentylchroman-7-yl)methanol

المذيبات

water

ethanol

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted three times with MTB ether
2. 2
   غسيلphases are washed with sat. sodium chloride soln
3. 3
   تجفيفand dried over sodium sulfate
4. 4
   أخرىthe solvent is removed in vacuo
5. 5
   ترشيحthe residue is filtered through silica gel with dichloromethane (Rf=0.3)

الإجراء التجريبي

11.1 g (44.3 mmol) of 6-fluoro-3-pentylchroman-7-carbaldehyde are dissolved in 100 ml of ethanol, and 2.0 g (52.8 mmol) of sodium borohydride are added in portions. After 3 h, the batch is diluted with water and extracted three times with MTB ether. The combined org. phases are washed with sat. sodium chloride soln. and dried over sodium sulfate, the solvent is removed in vacuo, and the residue is filtered through silica gel with dichloromethane (Rf=0.3), giving (6-fluoro-3-pentylchroman-7-yl)methanol as a colourless solid.

المصدر