تفاعل #2501969

معادلة التفاعل

compound

2-(5-hydroxypentylthio)-5-methylbenzimidazole

carbon tetrabromide

triphenylphosphine

→

title compound

المردود 67.4%

2-(5-bromopentylthio)-5-methylbenzimidazole

المردود 67.4%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solvent was evaporated under reduced pressure
2. 2
   أخرىThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1 to 2:2)

الإجراء التجريبي

1.4 g of the compound obtained in Example 14a and 2.8 g of carbon tetrabromide were added to 15 ml of tetrahydrofuran and then gradually added with 2.2 g of triphenylphosphine. After the reaction mixture was stirred at room temperature for 1 hour, the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1 to 2:2) to obtain 1.18 g of the title compound as yellow crystals (yield: 67%).

المصدر