تفاعل #2500395

معادلة التفاعل

n-pentadecanoic acid

DCC

6-amidino-2-naphthol methanesulfonate

→

white powder

المردود 41.2%

6-amidino-2-naphthyl pentadecanoate

المردود 41.2%

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGfurther stirred overnight at room temperature
2. 2
   ترشيحThe precipitate was collected by filtration
3. 3
   غسيلwashed with ethyl ether
4. 4
   workup.DISSOLUTIONwith acetone, dissolved in a methanol-dimethylformamide mixture
5. 5
   ترشيحfreed from the insolubles by filtration
6. 6
   تركيزconcentrated under reduced pressure
7. 7
   أخرىThe crystals formed upon addition of ethyl ether
8. 8
   أخرىwere recrystallized from methanol

الإجراء التجريبي

To a solution of 4.3 g of n-pentadecanoic acid in 50 ml of anhydrous pyridine, while being cooled in ice, was added 4.4 g of DCC. After stirring for 30 minutes, 5.0 g of 6-amidino-2-naphthol methanesulfonate was added to the mixture and further stirred overnight at room temperature. The precipitate was collected by filtration, washed with ethyl ether, then with acetone, dissolved in a methanol-dimethylformamide mixture, freed from the insolubles by filtration, and concentrated under reduced pressure. The crystals formed upon addition of ethyl ether were recrystallized from methanol to obtain 3.0 g of a white powder of 6-amidino-2-naphthyl pentadecanoate methanesulfonate.

المصدر