تفاعل #2492360

معادلة التفاعل

2-(4-acetylamino-phenoxy)-propionic acid methyl ester

2-(4-Acetylamino-phenoxy)-propionic acid methyl ester

→

63

المردود 98.1%

2-(4-Amino-phenoxy)-propionic acid

المردود 98.1%

المذيبات

hydrochloric acid

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled in vacuum
2. 2
   ترشيحfiltered hot
3. 3
   ترشيحfiltered
4. 4
   أخرىdried

الإجراء التجريبي

To a mixture 2-(4-acetylamino-phenoxy)-propionic acid methyl ester 62 (320 grams, 1.35 mol) in concentrated hydrochloric acid (8 liters) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 63 (240 grams, 81.7%) as a brown powder. The melting point was found to be 175-180° C.

المصدر