تفاعل #2490355

ord-b67040d8cf8246fe9e51c8f55ad16c65

معادلة التفاعل

N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2)CC1
(2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide
O=C([O-])C1CCN1C1CCC(F)(F)CC1.[Li+]
lithium 1-(4,4-difluorocyclohexyl)azetidine-2-carboxylate
→
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2CCN2C2CCC(F)(F)CC2)CC1
(2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(1-(4,4-difluorocyclohexyl)azetidine-2-carbonyl)pyrrolidine-2-carboxamide

المتفاعلات

N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2)CC1
(2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide
O=C([O-])C1CCN1C1CCC(F)(F)CC1.[Li+]
lithium 1-(4,4-difluorocyclohexyl)azetidine-2-carboxylate

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The reaction of (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide 7H and lithium 1-(4,4-difluorocyclohexyl)azetidine-2-carboxylate 20B carried out according to the general procedure L yielded (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(1-(4,4-difluorocyclohexyl)azetidine-2-carbonyl)pyrrolidine-2-carboxamide 1:1 epimers as an off-white solid (47%). MS ISP (m/e): 555.1 (100) [(M+H)]]+.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08802665B2uspto-grants-2014_08