تفاعل #2490354

ord-5f431a9f56b8402ab9ff177cfa62f3c5

معادلة التفاعل

N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2)CC1
(2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide
O=C([O-])C1CCN1C1CCCCC1.[Li+]
lithium 1-cyclohexylazetidine-2-carboxylate
→
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2CCN2C2CCCCC2)CC1
(2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(1-cyclohexylazetidine-2-carbonyl)pyrrolidine-2-carboxamide

المتفاعلات

N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2)CC1
(2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide
O=C([O-])C1CCN1C1CCCCC1.[Li+]
lithium 1-cyclohexylazetidine-2-carboxylate

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The reaction of (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide 7H and lithium 1-cyclohexylazetidine-2-carboxylate 20A carried out according to the general procedure L yielded (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(1-cyclohexylazetidine-2-carbonyl)pyrrolidine-2-carboxamide 1:1 epimers as an off-white solid (69%). MS ISP (m/e): 519.2 (100) [(M+H)]]+.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08802665B2uspto-grants-2014_08