تفاعل #2487439

معادلة التفاعل

2-fluoro-3-methylbenzonitrile

NBS

AIBN

→

crude material

3-(Bromomethyl)-2-fluorobenzonitrile

المذيبات

1,2-dichloroethane

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter complete consumption of the starting material (by TLC)
2. 2
   درجة الحرارةthe reaction mixture was cooled to RT
3. 3
   أخرىThe volatiles were removed under reduced pressure

الإجراء التجريبي

To a stirred solution of 2-fluoro-3-methylbenzonitrile (200 mg, 1.5 mmol) in 1,2-dichloroethane (30 ml) was added NBS (266 mg, 1.49 mmol) and AIBN (29 mg, 0.15 mmol) at RT. The reaction mixture was then heated to 80° C., and the reaction mixture was stirred for 2 h. After complete consumption of the starting material (by TLC), the reaction mixture was cooled to RT. The volatiles were removed under reduced pressure to obtain the crude material. Purification by silica gel column chromatography eluting with 2-3% EtOAc/hexane afforded compound I-6 (250 mg, 1.15 mmol, 78%) as colorless liquid. 1H NMR (500 MHz, CDCl3): δ 7.69-7.65 (m, 1H), 7.62-7.58 (m, 1H), 7.28-7.25 (m, 1H), 4.50 (s, 2H).

المصدر