تفاعل #2483598

معادلة التفاعل

2-Furoyl chloride

5-Amino-2-methylbenzoxazole

2,6-lutidine

→

product

المردود 87.1%

5-(2-Furancarboxamido)-2-methylbenzoxazole

المردود 87.1%

المذيبات

THF

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىthe temperature below 10° C
2. 2
   أخرىwas removed
3. 3
   workup.ADDITIONwas poured into 300 mL of water
4. 4
   أخرىThe solid was collected
5. 5
   غسيلwashed with water
6. 6
   أخرىdried

الإجراء التجريبي

5-Amino-2-methylbenzoxazole (14.8 g, 0.100 mol) and 2,6-lutidine (12.0 g, 0.111 mol) were combined with 100 mL of tetrahydrofuran (THF) and the solution was cooled to 3° C. in an ice-bath under nitrogen. 2-Furoyl chloride (13.7 g, 0.105 mol) in 20 ml of THF was added dropwise so as to keep the temperature below 10° C. After addition the ice-bath was removed and after stirring for 1 hr the mixture was poured into 300 mL of water. The solid was collected and washed with water and dried. This afforded 21.1 g (87% yield) of product; m.p. 156°-158° C.

المصدر