تفاعل #2482730

معادلة التفاعل

sodium metabisulphite

5-cyclopropyl-4-(2,2-difluoro-7-methylsulphenyl-1,3-benzodioxol-4-oyl)isoxazole

m-chloroperbenzoic acid

→

5-cyclopropyl-4-(2,2-difluoro-7-methylsulphonyl-1,3-benzodioxol-4-oyl)isoxazole

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe filtered solution was separated
2. 2
   غسيلthe organic phase washed with sodium acetate solution, brine
3. 3
   تجفيفdried over anhydrous sodium sulphate
4. 4
   أخرىevaporated

الإجراء التجريبي

A solution of 5-cyclopropyl-4-(2,2-difluoro-7-methylsulphenyl-1,3-benzodioxol-4-oyl)isoxazole (0.64 g) in dichloromethane was treated with m-chloroperbenzoic acid (55%, 1.5 g). After 2 hours the mixture was cooled to 1° C., and 1M sodium metabisulphite solution added. The filtered solution was separated and the organic phase washed with sodium acetate solution, brine, dried over anhydrous sodium sulphate and evaporated to give 5-cyclopropyl-4-(2,2-difluoro-7-methylsulphonyl-1,3-benzodioxol-4-oyl)isoxazole (compound 5, 0.35 g) as a white solid, m.p. 164°-165° C.

المصدر