تفاعل #2474105

معادلة التفاعل

2-ethyl-4H-3,1-benzoxazin-4-one

4-aminophenol

→

compound

المردود 66.0%

2-ethyl-3-(4-hydroxyphenyl)-4-(3H)-quinazolinone

المردود 66.0%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter leaving
2. 2
   درجة الحرارةto cool to room temperature
3. 3
   workup.DISTILLATIONdistilled water (94 mL)
4. 4
   workup.ADDITIONwas added
5. 5
   ترشيحthe solid precipitate was filtered off
6. 6
   أخرىThe product was recrystallized (ethanol)

الإجراء التجريبي

2-ethyl-4H-3,1-benzoxazin-4-one (6.5 g, 37.1 mmol) and 4-aminophenol (4.05 g, 37.1 mmol) were dissolved in dimethylformamide (18 mL) and stirred at 140° C. for 10 hours. After leaving to cool to room temperature, distilled water (94 mL) was added, and the solid precipitate was filtered off. The product was recrystallized (ethanol) and the target compound (6.52 g, 66%) was obtained as light brown crystals.

المصدر