تفاعل #2468020

معادلة التفاعل

ethyl 2-methyl-2-(tetrahydro-2H-pyran-2-yloxy)propanoate

lithium hydroxide

→

title compound

المردود 96.6%

2-Methyl-2-(tetrahydro-2H-pyran-2-yloxy)propanoic acid

المردود 96.6%

المذيبات

tetrahydrofuran

methanol

water

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic solvents were removed under reduced pressure
2. 2
   استخلاصThe formed precipitate was extracted with ethyl ether (3×25 mL)
3. 3
   غسيلThe combined organic layers were washed with brine
4. 4
   تجفيفdried over anhydrous sodium sulphate
5. 5
   تركيزconcentrated

الإجراء التجريبي

To a solution of ethyl 2-methyl-2-(tetrahydro-2H-pyran-2-yloxy)propanoate (0.5 g, 2.31 mmol) in tetrahydrofuran (2 mL) and methanol (6 mL) was added a solution of lithium hydroxide (0.277 g, 11.56 mmol) in water (6 mL). The resulting mixture was stirred at room temperature overnight. The organic solvents were removed under reduced pressure and the resulting aqueous phase was acidified using hydrochloric acid 2N until pH=4. The formed precipitate was extracted with ethyl ether (3×25 mL). The combined organic layers were washed with brine, dried over anhydrous sodium sulphate and concentrated to yield the title compound (0.42 g, 96%) as a colourless oil.

المصدر