تفاعل #2468017

معادلة التفاعل

ethyl [2-(4-iodopyridin-2-yl)hydrazino](oxo)acetate

lithium hydroxide

hydrochloric acid

→

title compound

المردود 158.9%

[2-(4-Iodopyridin-2-yl)hydrazino](oxo)acetic acid

المردود 158.9%

المذيبات

Water

tetrahydrofuran

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe formed precipitate was filtered
2. 2
   غسيلrinsed with water
3. 3
   أخرىdried under vacuum

الإجراء التجريبي

To a solution of ethyl [2-(4-iodopyridin-2-yl)hydrazino](oxo)acetate (0.15 g, 0.41 mmol) in tetrahydrofuran (3.5 mL) was added dropwise a solution of lithium hydroxide (0.030 g, 1.25 mmol) in water (1.5 mL). The resulting mixture was stirred at room temperature for 1 hour. Water was added and it was acidified using hydrochloric acid 2N until pH=3. The formed precipitate was filtered, rinsed with water and dried under vacuum to yield the title compound (0.20 g, 94%) as a white solid.

المصدر