تفاعل #2468015

معادلة التفاعل

2,5-difluoro-4-iodopyridine

hydrazine hydrate

→

title compound

المردود 35.0%

5-Fluoro-2-hydrazinyl-4-iodopyridine

المردود 35.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   تركيزThe mixture was concentrated in vacuum
2. 2
   أخرىthe resulting solid triturated with water
3. 3
   ترشيحfiltered
4. 4
   غسيلrinsed with more water
5. 5
   أخرىdried

الإجراء التجريبي

A solution of 2,5-difluoro-4-iodopyridine (1.35 g, 5.602 mmol) in ethanol (7 mL) was treated with hydrazine hydrate (2.75 mL) and the mixture was stirred at 50° C. for 19 hours. The mixture was concentrated in vacuum and the resulting solid triturated with water, filtered, rinsed with more water and dried to yield the title compound (0.57 g, 35%) that was used in the following steps without further purification.

المصدر