تفاعل #2468007

معادلة التفاعل

benzyl 4-(4-nitro-phenyl)-piperazine-1-carboxylate

→

benzyl 4-(4-amino-phenyl)-piperazine-1-carboxylate

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحThen the mixture is filtered
2. 2
   أخرىto remove the catalyst, 70 mL of 1 N aqueous hydrochloric acid
3. 3
   workup.ADDITIONare added

الإجراء التجريبي

11.28 g benzyl 4-(4-nitro-phenyl)-piperazine-1-carboxylate are dissolved in 500 mL MeOH and combined with 1 g Raney nickel. The mixture is hydrogenated for 18 h at 5 bar H2 pressure. Then the mixture is filtered to remove the catalyst, 70 mL of 1 N aqueous hydrochloric acid are added and the solvent is eliminated in vacuo.

المصدر