تفاعل #2467994

معادلة التفاعل

3-amino-5-phenylthiophene-2-carbonitrile

ethanol

→

solid

المردود 45.0%

3-Amino-5-phenylthiophene-2-carboxamide

المردود 45.0%

المذيبات

sodium hydroxide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was refluxed for 1 h
2. 2
   أخرىto attain rt
3. 3
   أخرىthe crystals separated
4. 4
   ترشيحwere filtered off
5. 5
   غسيلwashed with cold water
6. 6
   أخرىdried

الإجراء التجريبي

To a suspension of 3-amino-5-phenylthiophene-2-carbonitrile (150 mg) in aqueous sodium hydroxide solution (20 mL, 10%) was added ethanol (10 mL) and the mixture was refluxed for 1 h. The reaction mixture was allowed to attain rt and the crystals separated were filtered off, washed with cold water and dried to give the product as a golden yellow color solid (70 mg, 45%), mp 180-182° C.

المصدر