تفاعل #2467985

معادلة التفاعل

Methyl 4-aminothiophene-3-carboxylate hydrochloride

ammonia

→

oil

المردود 65.0%

Methyl 4-aminothiophene-3-carboxylate

المردود 65.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe solution was extracted with chloroform
2. 2
   غسيلthe combined chloroform layer was washed with water, brine
3. 3
   تجفيفdried over sodium sulfate
4. 4
   ترشيحThe solution was filtered
5. 5
   أخرىevaporated the solvent

الإجراء التجريبي

Methyl 4-aminothiophene-3-carboxylate hydrochloride (290 mg) was dissolved in water (20 mL) and basified with ammonia solution. The solution was extracted with chloroform and the combined chloroform layer was washed with water, brine and dried over sodium sulfate. The solution was filtered and evaporated the solvent to give the product as pale yellow color oil (150 mg, 65%). 1H NMR (400 MHz, CDCl3): δ 7.92 (1H, d, J=3.6 Hz), 6.08 (1H, d, J=3.6 Hz), 4.79 (2H, br s), 3.85 (3H, s).

المصدر