تفاعل #2467938

معادلة التفاعل

4b

3-Phenyl-2-[(4-phenyl-thiazol-2-yl)-hydrazono]-propionic acid

MeOH

thionylchloride

→

desired product

3-Phenyl-2-[(4-phenyl-thiazol-2-yl)-hydrazono]-propionic acid methyl ester

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was heated
2. 2
   درجة الحرارةto reflux
3. 3
   تركيزconcentrated

الإجراء التجريبي

To a suspension of 4b (0.1 mmol, 34 mg) in MeOH (2 mL), was added dropwise thionylchloride (22 μL, 0.3 mmol) at −30° C. Then, the solution was allowed to warm at room temperature. The reaction mixture was heated to reflux and concentrated to afford the desired product. The crude is purified by silica gel chromatography (EtOAc/MeOH 10/1) to give the pure compound as a yellow solid (11 mg, 32%).

المصدر