تفاعل #2463892

معادلة التفاعل

(4-{[2-(2-chloro-benzylamino)-5-cyano-pyridin-4-ylamino]-methyl}-cyclohexylmethyl)-carbamic acid tert-butyl ester

HCl dioxane

→

4-[(4-aminomethyl-cyclohexylmethyl)-amino]-6-(2-chloro-benzylamino)-nicotinonitrile

المردود 114.6%

ظروف التفاعل

المعالجة

1. 1
   أخرىEvaporation of the volatiles in vacuo

الإجراء التجريبي

A mixture of (4-{[2-(2-chloro-benzylamino)-5-cyano-pyridin-4-ylamino]-methyl}-cyclohexylmethyl)-carbamic acid tert-butyl ester (12 mg, 0.025 mmol) and 4 N HCl/dioxane (3 mL) was stirred at ambient temperature for 18 h. Evaporation of the volatiles in vacuo afforded the HCl salt of 4-[(4-aminomethyl-cyclohexylmethyl)-amino]-6-(2-chloro-benzylamino)-nicotinonitrile as a white solid (11 mg, 100%), m/z 384 (M+H)+.

المصدر