تفاعل #2460179

معادلة التفاعل

sodium methylate

4-cyanophenyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside

→

expected product

المردود 129.5%

4-cyanophenyl 5-thio-β-D-xylopyranoside

المردود 129.5%

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONneutralized by the addition of Amberlite® IR 120 H+ resin
2. 2
   ترشيحfiltered
3. 3
   أخرىAfter evaporation to dryness
4. 4
   أخرىthe residue is crystallized from methanol

الإجراء التجريبي

1.5 ml of a solution of sodium methylate in methanol (8% w/v of Na) are added under an inert atmosphere to a suspension of 10 g (25.4.10-3 ) of 4-cyanophenyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside in 200 ml of methanol. The reaction mixture is stirred at room temperature for 30 min, neutralized by the addition of Amberlite® IR 120 H+ resin and filtered. After evaporation to dryness, the residue is crystallized from methanol to give 8.8 g (yield: 73%) of the expected product.

المصدر