تفاعل #2446146

معادلة التفاعل

4-bromo-2-nitroaniline

2-chloroacetyl chloride

→

N-(4-bromo-2-nitrophenyl)-2-chloroacetamide

المردود 96.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter refluxing for 1.5 h
2. 2
   أخرىthe solvent was removed under reduced pressure
3. 3
   أخرىCrystallization from ethyl acetate/hexane

الإجراء التجريبي

To a solution of 4-bromo-2-nitroaniline (15.0 g, 69.1 mmol) was added drop wise 2-chloroacetyl chloride (9.4 g, 82.9 mmol) under nitrogen. After refluxing for 1.5 h, the reaction mixture was cooled to ambient temperature and the solvent was removed under reduced pressure. Crystallization from ethyl acetate/hexane afforded N-(4-bromo-2-nitrophenyl)-2-chloroacetamide (19.4 g, 66.1 mmol, 96%) as yellow needles.

المصدر