تفاعل #2446144

معادلة التفاعل

water

4-bromo-2-fluoroaniline

acetoxyacetyl chloride

→

2-(4-bromo-2-fluorophenylamino)-2-oxoethyl acetate

المردود 104.8%

المذيبات

CHCl3

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe solution was extracted several times with dichloromethane
2. 2
   غسيلThe combined organic layers were washed with brine
3. 3
   تجفيفdried over MgSO4
4. 4
   أخرىevaporated

الإجراء التجريبي

To a solution of 4-bromo-2-fluoroaniline (9.5 g, 50.0 mmol) in 150 ml dry CHCl3 was added drop wise acetoxyacetyl chloride (7.5 g, 55.0 mmol) under nitrogen. The mixture was stirred at room temperature for 0.5 h, then water was added and the solution was extracted several times with dichloromethane. The combined organic layers were washed with brine, dried over MgSO4 and evaporated, affording 2-(4-bromo-2-fluorophenylamino)-2-oxoethyl acetate (15.2 g) as colorless solid in quantitative yield.

المصدر