تفاعل #2439959
ord-595e417efb4e4157a8963a91b7e80c40
معادلة التفاعل
المتفاعلات
الكواشف
المذيبات
ظروف التفاعل
المعالجة
- 1أخرىA small screw cap test tube
- 2درجة الحرارةSubsequently, the reaction mixture was cooled to room temperature
- 3غسيلThe solution was washed with water (2 mL)
- 4غسيلthe water layer was re-washed with additional EtOAc (2 mL)
- 5تركيزThe combined organic layers were then concentrated in vacuo
- 6أخرىaffording the crude product
- 7أخرىThe crude product was further purified by silica gel column chromatography with 5% methanol in chloroform as eluant
الإجراء التجريبي
A small screw cap test tube was charged with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indol-5-ylmethyl)-phenyl]-amide (prepared below, 70 mg, 0.175 mmol) and THF (1 mL). To the resulting solution was added 4-(4-Methyl-piperazin-1-yl)-phenylamine (66.8 mg, 0.349 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature and then diluted with EtOAc (2 mL). The solution was washed with water (2 mL) and the water layer was re-washed with additional EtOAc (2 mL). The combined organic layers were then concentrated in vacuo affording the crude product. The crude product was further purified by silica gel column chromatography with 5% methanol in chloroform as eluant to give the desired product as a solid in 55% yield (55 mg, 0.96 mmol).