تفاعل #2439958

معادلة التفاعل

N-[4-(3-Hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-acetamide

THF

5-Amino-2-methoxy-phenol

→

title compound

المردود 63.0%

N-(4-{3-[(3-Hydroxy-4-methyl-phenylamino)-methylene]-2-oxo-2,3-dihydro-1H-indole-5-carbonyl}-phenyl)-acetamide

المردود 63.0%

المذيبات

ظروف التفاعل

المعالجة

1. 1
   أخرىA small screw cap test tube
2. 2
   درجة الحرارةSubsequently, the reaction mixture was cooled to room temperature
3. 3
   أخرىThe solid precipitate that formed

الإجراء التجريبي

A small screw cap test tube was charged with N-[4-(3-Hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-acetamide (as prepared in Example 11, 50 mg, 0.155 mmol) and THF (2 mL). To the resulting solution was added 5-Amino-2-methoxy-phenol (21.0 mg, 0.170 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature. Hexanes were added to the reaction mixture. The solid precipitate that formed was washed with ˜1 mL of i-prOH yielding 63% (42 mg, 0.098 mmol) of the title compound.

المصدر