تفاعل #2439936

معادلة التفاعل

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide

N-(4-aminophenyl)morpholine

→

title compound

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid (3-{3-[(4-morpholin-4-yl-phenylamino)-methylene]-2-oxo-2,3-dihydro-1H-indole-5-carbonyl}-phenyl)-amide

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىA small screw cap test tube
2. 2
   درجة الحرارةSubsequently, the reaction mixture was cooled to room temperature
3. 3
   تركيزconcentrated in vacuo
4. 4
   workup.DISSOLUTIONredissolved in EtOAc
5. 5
   workup.ADDITIONHexanes were added to the reaction mixture
6. 6
   أخرىThe solid precipitate that formed
7. 7
   ترشيحwas filtered

الإجراء التجريبي

A small screw cap test tube was charged with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide (prepared below, 30 mg, 0.072 mmol) and THF (1 mL). To the resulting solution was added N-(4-aminophenyl)morpholine (19.3 mg, 0.1082 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature, concentrated in vacuo and redissolved in EtOAc. Hexanes were added to the reaction mixture. The solid precipitate that formed was filtered and washed with ˜1 mL of ice cold THF yielding 36% (15 mg, 0.026 mmol) of the title compound.

المصدر