تفاعل #2410

معادلة التفاعل

2-(6-aminopyrimidin-4-yloxy)ethanol

bromine

→

2-(6-amino-5-bromopyrimidin-4-yloxy)ethanol

المردود 104.7%

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture is evaporated
2. 2
   أخرىto remove the solvent
3. 3
   workup.DISSOLUTIONthe residue is dissolved in ethyl acetate
4. 4
   workup.ADDITIONThe mixture is treated with saturated aqueous sodium hydrogen carbonate solution
5. 5
   استخلاصextracted with ethyl acetate/tetrahydrofuran
6. 6
   غسيلThe organic layer is washed
7. 7
   أخرىdried
8. 8
   أخرىevaporated
9. 9
   أخرىto remove the solvent

الإجراء التجريبي

To a suspension of 2-(6-aminopyrimidin-4-yloxy)ethanol (400 mg) in methanol (4 ml) is added dropwise a solution of bromine (437 mg) in methanol (2 ml). The mixture is evaporated to remove the solvent, and the residue is dissolved in ethyl acetate. The mixture is treated with saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate/tetrahydrofuran. The organic layer is washed, dried, and evaporated to remove the solvent to give 2-(6-amino-5-bromopyrimidin-4-yloxy)ethanol (632 mg).

المصدر