تفاعل #2409

معادلة التفاعل

2-(6-azidopyrimidin-4-yloxy)ethanol

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2-(6-aminopyrimidin-4-yloxy)ethanol

المردود 79.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe catalyst is removed by filtration
2. 2
   تركيزthe filtrate is concentrated
3. 3
   أخرىThe residue is recrystallized from ethanol/diethyl ether

الإجراء التجريبي

A mixture of 2-(6-azidopyrimidin-4-yloxy)ethanol (1.64 g), 10% palladium-carbon (0.25 g) and ethanol (20 ml) is subjected to catalytic hydrogenation at room temperature for one hour under hydrogen atmosphere (1 atm). The catalyst is removed by filtration, and the filtrate is concentrated. The residue is recrystallized from ethanol/diethyl ether to give 2-(6-aminopyrimidin-4-yloxy)ethanol (1.11 g).

المصدر