تفاعل #2407

معادلة التفاعل

4,6-dichloropyrimidine

ethylene glycol

sodium hydride

→

2-(6-chloropyrimidin-4-yloxy)ethanol

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooling
2. 2
   أخرىevaporated
3. 3
   أخرىto remove the solvent
4. 4
   استخلاصThe residue is extracted with ethyl acetate
5. 5
   استخلاصthe ethyl acetate extract
6. 6
   أخرىis dried
7. 7
   تركيزconcentrated under reduced pressure
8. 8
   أخرىThe residue is purified by silica gel column chromatography (solvent; chloroform/ethyl acetate=5:1~2:1)

الإجراء التجريبي

To a mixture of 4,6-dichloropyrimidine (5.0 g), ethylene glycol (100 ml) and tetrahydrofuran (100 ml)is added sodium hydride (60% dispersion-type, 1.34 g) under ice-cooling. The mixture is stirred at the same temperature for two hours, and evaporated to remove the solvent. The residue is extracted with ethyl acetate, and the ethyl acetate extract is dried, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (solvent; chloroform/ethyl acetate=5:1~2:1) to give 2-(6-chloropyrimidin-4-yloxy)ethanol (5.67 g) as an oily product.

المصدر