تفاعل #2399

معادلة التفاعل

2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol

→

2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol

المردود 89.7%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىis subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere
2. 2
   أخرىfor one hour
3. 3
   أخرىThe catalyst is removed by filtration
4. 4
   تركيزthe filtrate is concentrated under reduced pressure
5. 5
   أخرىThe residue is recrystallized from ethyl acetate/n-hexane

الإجراء التجريبي

A mixture of 2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol (19.6 g), 10% palladium-carbon (50% moist) (4.0 g) and ethanol (240 ml) is subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere (1 atm) for one hour. The catalyst is removed by filtration, and the filtrate is concentrated under reduced pressure. The residue is recrystallized from ethyl acetate/n-hexane to give 2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (15.9 g).

المصدر