تفاعل #2398

معادلة التفاعل

2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol

sodium azide

dimethyformamide

→

2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol

المردود 87.5%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis heated
2. 2
   درجة الحرارةAfter cooling
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   غسيلThe ethyl acetate layer is washed
5. 5
   أخرىdried
6. 6
   أخرىevaporated
7. 7
   أخرىto remove the solvent
8. 8
   أخرىThe residue is crystallized from hexane

الإجراء التجريبي

A mixture of 2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol (21.85 g), sodium azide (10.7 g) and dimethyformamide (260 ml) is heated with stirring at 75°-80° C. overnight. After cooling, the mixture is treated with water, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from hexane to give 2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (19.6 g).

المصدر