تفاعل #2383764

ord-dfd5ee8d4f8142afabf7ec74d7a7bb2d

معادلة التفاعل

Cc1n[nH]cc1Cl
4-chloro-3-methylpyrazole
C=O
formalin
Cc1nn(CO)cc1Cl
solid
المردود 95.0%
Cc1nn(CO)cc1Cl
N-hydroxymethyl-4-chloro-3-methylpyrazole
المردود 95.0%

الكواشف

لا شيء

المذيبات

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىWater and methanol were then evaporated

الإجراء التجريبي

116 g (1.0 mol) of 4-chloro-3-methylpyrazole in 50 ml of methanol were dissolved in 100 g (1.0 mol) of formalin solution (30%) at room temperature. Water and methanol were then evaporated. The title compound remained as a white solid (yield 95%).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06488734B1uspto-grants-2002_12