تفاعل #2380

معادلة التفاعل

4-tert-butyl-N-{6-[2-(4-benzyloxyphenoxy)ethoxy]-5-(4-methylphenyl)pyrimidin-4-yl}benzensulfonamide

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4-tert-butyl-N-{6-[2-(4-hydroxyphenoxy)ethoxy]-5-(4-methylphenyl)pyrimidin-4-yl}benzenesulfonamide

المردود 97.9%

المذيبات

ethanol tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىis subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere
2. 2
   أخرىfor 24 hours
3. 3
   أخرىThe catalyst is removed by filtration
4. 4
   تركيزthe filtrate is concentrated
5. 5
   أخرىThe residue is crystallized from ethyl acetate/diisopropyl ether

الإجراء التجريبي

A mixture of 4-tert-butyl-N-{6-[2-(4-benzyloxyphenoxy)ethoxy]-5-(4-methylphenyl)pyrimidin-4-yl}benzensulfonamide (3.95 g), 10% palladium-carbon (1.5 g) and ethanol-tetrahydrofuran (80 ml-80 ml) is subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere (1 atm) for 24 hours. The catalyst is removed by filtration, and the filtrate is concentrated. The residue is crystallized from ethyl acetate/diisopropyl ether to give 4-tert-butyl-N-{6-[2-(4-hydroxyphenoxy)ethoxy]-5-(4-methylphenyl)pyrimidin-4-yl}benzenesulfonamide (3.31 g).

المصدر