تفاعل #2364150

معادلة التفاعل

mixture

(S)-[tert-Butoxycarbonyl-(4-nitro-benzyl)-amino]-phenyl-acetic acid cyclopentyl ester

→

solid

المردود 90.0%

(S)-[(4-Amino-benzyl)-tert-butoxycarbonyl-amino]-phenyl-acetic acid cylopentyl ester

المردود 90.0%

المذيبات

EtOAc

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe Pd/C catalyst was filtered off through a pad of celite
2. 2
   تركيزThe filtrate was concentrated under reduced pressure

الإجراء التجريبي

A mixture of Stage 2 product (12 g, 26.4 mmol) and 10% Pd/C (2.0 g) in EtOAc (350 ml) was hydrogenated at room temperature for 18 h. The Pd/C catalyst was filtered off through a pad of celite. The filtrate was concentrated under reduced pressure to yield a white solid (10.1 g, 90% yield). LCMS purity 100%, m/z 425 [M++H]+, 466 [M++H+41]+.

المصدر