تفاعل #2358515

معادلة التفاعل

1-(2-bromoethoxy)-3-fluoro-5-methylsulfonyl-benzene

piperidine

→

title compound

المردود 94.8%

1-[2-(3-fluoro-5-methylsulfonyl-phenoxy)ethyl]piperidine

المردود 94.8%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىPreparation
2. 2
   أخرىPurification by flash column chromatography (ethyl acetate/methanol, 100:0 to 85:15)

الإجراء التجريبي

Preparation according to Example 1 but performed in one portion: 1-(2-bromoethoxy)-3-fluoro-5-methylsulfonyl-benzene (0.5 g, 1.68 mmol) and piperidine (1.33 ml, 13.46 mmol) in ethanol (5 ml). Purification by flash column chromatography (ethyl acetate/methanol, 100:0 to 85:15) gave the title compound (480 mg, 94.7%). The amine was converted to the hydrochloric acid salt and re-crystallized from methanol/diethyl ether: M.p. 194.6° C. MS m/z (relative intensity, 70 eV) 301(M+, 1), 99 (8), 98 (bp), 96 (4), 55 (5).

المصدر