تفاعل #2358486

معادلة التفاعل

2-fluoro-4-(trifluoromethyl)benzaldehyde

methyl thioglycolate

potassium carbonate

DMF

→

methyl-6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate

المردود 56.4%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction mixture was cooled to room temperature
2. 2
   استخلاصextracted with tert-butyl methyl ether 3 times
3. 3
   غسيلThe combined organic layer was washed with water
4. 4
   تجفيفThe mixture was dried over magnesium sulfate
5. 5
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

A mixture of 1.11 g of 2-fluoro-4-(trifluoromethyl)benzaldehyde, 739 mg of methyl thioglycolate, 1.3 g of potassium carbonate and 20 ml of DMF was stirred at 140° C. for 2 hours, and then the reaction mixture was cooled to room temperature. To the reaction mixture was added water, and then extracted with tert-butyl methyl ether 3 times. The combined organic layer was washed with water, followed by saturated aqueous sodium chloride solution. The mixture was dried over magnesium sulfate, and then concentrated under reduced pressure to obtain 848 mg of methyl-6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate (the present compound 2).

المصدر