تفاعل #2348100

معادلة التفاعل

4-pentylphenylboric acid

potassium carbonate

compound ( 21 )

3-iodo-4,5-difluorotoluene

→

3,4-difluoro-5-(4-pentylphenyl)toluene

المردود 99.0%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder refluxing
2. 2
   درجة الحرارةby heating for 4 hours
3. 3
   أخرىAfter removing Pd/C
4. 4
   ترشيحby filtration
5. 5
   أخرىthe filtrate was separated
6. 6
   استخلاصthe aqueous layer as extracted with toluene, which
7. 7
   workup.ADDITIONwas added to the organic layer
8. 8
   غسيلThe organic layer was washed with a saturated potassium hydrogensulfite aqueous solution and saturated saline
9. 9
   تجفيفdried over anhydrous magnesium sulfate
10. 10
    workup.DISTILLATIONThe solvent was distilled off
11. 11
    أخرىthe residue was purified by silica gel column chromatography

الإجراء التجريبي

5.74 g of TBAB, 9.84 g of potassium carbonate and 0.76 g of Pd/C were added to 9.04 g of the compound (21) having been dissolved in a mixed solvent of 50 mL of toluene and 50 mL of Solmix, and 6.84 g of 4-pentylphenylboric acid, followed by stirring under refluxing by heating for 4 hours. After removing Pd/C by filtration, the filtrate was separated, and the aqueous layer as extracted with toluene, which was added to the organic layer. The organic layer was washed with a saturated potassium hydrogensulfite aqueous solution and saturated saline, and dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 8.93 g of 3,4-difluoro-5-(4-pentylphenyl)toluene (22).

المصدر