تفاعل #2341199

ord-30e186780f784fa4a9d3d367033dac61

معادلة التفاعل

NC(CO)(CO)CO
Tris base
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)CCC(=O)O)CC[C@]4(C)[C@H]3CC[C@]12C
Cholesterol hydrogen succinate
NC(CO)(CO)CO
Tris
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
cholesterol
N#CI
ICN
→
CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Pregnanolone

المتفاعلات

NC(CO)(CO)CO
Tris base
—
cholesterol hemisuccinate Tris
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)CCC(=O)O)CC[C@]4(C)[C@H]3CC[C@]12C
Cholesterol hydrogen succinate
NC(CO)(CO)CO
Tris
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
cholesterol
N#CI
ICN

الكواشف

لا شيء

المذيبات

O
water

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    workup.DISSOLUTIONwas dissolved in 1.5 liters of diethyl either
  2. 2
    أخرىdried for 12 hours
  3. 3
    أخرىafter which the cholesterol hemisuccinate Tris salt product was recrystallized three times from about 5-liter volumes of boiling ethyl acetate

الإجراء التجريبي

The cholesterol hemisuccinate Tris salt had been prepared as follows Cholesterol hydrogen succinate (50.3 g, 0.11 moles) from ICN, Cleveland, Ohio, was dissolved in 1.5 liters of diethyl either. Tris base (12.1 g, 0.1 moles) from Fisher, Fairlawn, N.J., was dissolved in 30 ml of water. The Tris solution was then added to the cholesterol solution, and the resulting solution was rotoevaporated to a milky wet residue. The milky residue was freeze dried for 12 hours, after which the cholesterol hemisuccinate Tris salt product was recrystallized three times from about 5-liter volumes of boiling ethyl acetate.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US05234634uspto-grants-1993_08