تفاعل #2336553

معادلة التفاعل

3-bromo-6-chloro-2-fluorobenzaldehyde

sodium borohydride

→

(3-bromo-6-chloro-2-fluorophenyl) methanol

المردود 51.2%

المذيبات

water

ethanol

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ethyl acetate (2×200 mL)
2. 2
   تجفيفdried (sodium sulfate)
3. 3
   تركيزconcentrated
4. 4
   أخرىThe crude solid was recrystallized from hexanes

الإجراء التجريبي

To a solution of 3-bromo-6-chloro-2-fluorobenzaldehyde (20.0 g, 0.084 mol) in ethanol (250 mL) was added sodium borohydride (6.4 g, 0.168 mol) and the reaction mixture was stirred at ambient temperature for 1 hour. The mixture was diluted with water (300 mL) and extracted with ethyl acetate (2×200 mL), dried (sodium sulfate) and concentrated. The crude solid was recrystallized from hexanes to give (3-bromo-6-chloro-2-fluorophenyl) methanol (10.4 g, 0.043 mol): 1H NMR (CDCl3): δ 7.50 (m, 1H), 7.15 (dt, 1H), 4.90 (s, 2H), 2.10 (bs, 1H).

المصدر