تفاعل #2336532

معادلة التفاعل

Water

Thiophenol

potassium carbonate

DMF

→

title compound

المردود 52.0%

3,6-Bis(phenylthio) phthalonitrile

المردود 52.0%

ظروف التفاعل

المعالجة

1. 1
   ترشيحthen filtered
2. 2
   أخرىThe filter cake was purified by flash column chromatography (gradient elution 10%-30% ethyl acetate:isohexane)

الإجراء التجريبي

Thiophenol (11.75 g, 107 mmol), potassium carbonate (14.74 g, 107 mmol) and ditosylated dicyanohydroquinone (25.00 g, 53.0 mmol) in DMF (80 mL) were reacted as described above. Water (100 mL) was added and the mixture stirred for 1 hour then filtered. The filter cake was purified by flash column chromatography (gradient elution 10%-30% ethyl acetate:isohexane) to give the title compound as a yellow solid (5.53 g, 16.1 mmol, 52%). [Found: C, 69.6%; H, 3.5%; N, 8.2%; S, 18.3%; C20H12N2S2 requires C, 69.8%; H, 3.5%; N, 8.1%; S, 18.6%]; MS (EI+) 344 (M+, 100%).

المصدر