تفاعل #2336518

معادلة التفاعل

Ethyl 4-hydroxypyrimidine-5-carboxylate

LiOH.H2O

→

title compound 19

4-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID

المذيبات

THF

MeOH

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was quenched with conc. HCl (1 mL)
2. 2
   استخلاصextracted with EtOAc (2×20 mL)
3. 3
   استخلاصThe combined organic extract
4. 4
   تجفيفwas dried (MgSO4)
5. 5
   تركيزconcentrated

الإجراء التجريبي

Ethyl 4-hydroxypyrimidine-5-carboxylate can be prepared following the procedure of M. Pesson et al., Eur. J. Med. Chem.—Chim. Ther. 1974, 9, 585. A solution of this ester (500 mg, 3 mmol) in THF (10 mL) and MeOH (5 mL) was treated with LiOH.H2O (373 mg, 8.9 mmol) and stirred overnight. The mixture was quenched with conc. HCl (1 mL) and extracted with EtOAc (2×20 mL). The combined organic extract was dried (MgSO4) and concentrated to give 260 mg of the title compound 19 as an orange solid, m.p. 220° C. (dec). 4-HYDROXY-2-METHYLPYRIMIDINE-5-CARBOXYLIC ACID (20).

المصدر