تفاعل #2335938

معادلة التفاعل

water

propionyloxyacetyl chloride

2-amino-6-(ethylamino)benzonitrile

pyridine

→

title compound

2-(ethylamino)-6-(propionyloxyacetylamino)benzonitrile

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis cooled in an ice bath
2. 2
   استخلاصthe mixture is extracted with methylene chloride
3. 3
   تجفيفThe organic layer is dried over anhydrous sodium sulfate
4. 4
   workup.DISTILLATIONthe solvent is distilled off under reduced pressure
5. 5
   أخرىThe resulting crude crystals are recrystallized from ethanol

الإجراء التجريبي

To a solution of 2-amino-6-(ethylamino)benzonitrile (2.3 g) in methylene chloride (50 ml) is added pyridine (1.6 ml), and thereto is added dropwise propionyloxyacetyl chloride (3.0 ml) which is cooled in an ice bath. The mixture is stirred at room temperature for 1 hour, and thereafter, water is added thereto, and the mixture is extracted with methylene chloride. The organic layer is dried over anhydrous sodium sulfate, and the solvent is distilled off under reduced pressure. The resulting crude crystals are recrystallized from ethanol to give the title compound (1.6 g) having the following physical properties.

المصدر