تفاعل #2328975

معادلة التفاعل

trans-4-vinyl cyclohexane carboxylic acid

trimethylsilyl chloride

→

methyl trans-4-vinylcyclohexanecarboxylate

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةby refluxing for 6 hours
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   workup.ADDITION150 mL of hexane was added
4. 4
   أخرىthe methanol layer was separated
5. 5
   استخلاصthe methanol layer was extracted with hexane
6. 6
   غسيلthe mixture was washed with saturated saline
7. 7
   تجفيفThe organic layer was dried over anhydrous sodium sulfate
8. 8
   تركيزconcentrated

الإجراء التجريبي

All of trans-4-vinyl cyclohexane carboxylic acid was dissolved in 120 mL of methanol and 0.1 g of trimethylsilyl chloride was added, followed by refluxing for 6 hours. The solution was cooling to room temperature and then concentrated under reduced pressure. 150 mL of hexane was added and the methanol layer was separated, and then the methanol layer was extracted with hexane. After combining with the organic layer, the mixture was washed with saturated saline. The organic layer was dried over anhydrous sodium sulfate and then concentrated to obtain 29.5 g of methyl trans-4-vinylcyclohexanecarboxylate.

المصدر