تفاعل #2328

معادلة التفاعل

Methyl 4-(2,2-dimethylbromoacetyl)phenoxyacetate

1-(4-pyridyl)piperazine

→

title compound

Methyl 4-[2-[4-(4-pyridyl)piperazin-1-yl]-2,2-dimethyl-acetyl]phenoxyacetate

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solid formed
2. 2
   أخرىwas removed by filtration
3. 3
   أخرىthe filtrate evaporated
4. 4
   أخرىto give an oil
5. 5
   أخرىPurification by flash chromatography on silica
6. 6
   غسيلeluting with 0.5 to 4.0% v/v methanol/dichloromethane

الإجراء التجريبي

Methyl 4-(2,2-dimethylbromoacetyl)phenoxyacetate (1.58 g) was added to a stirred solution of 1-(4-pyridyl)piperazine (1.63 g) in acetonitrile (40 ml). After 34 days, the solid formed was removed by filtration and the filtrate evaporated to give an oil. Purification by flash chromatography on silica, eluting with 0.5 to 4.0% v/v methanol/dichloromethane gave the title compound, 240 mg, as a white foam: NMR (d6DMSO) δ 8.49 (2H, d), 8.12 (2H, d), 6.96 (2H, d), 6.77 (2H, d), 4.87 (2H, s), 3.69 (3H, s), 3.28 (4H, t), 2.58 (4H, t), 1.25 (6H, s); m/e 398 (M+H)+ ; calculated for C22H27N3O4.0.25H2O: C, 65.7; H, 6.8; N, 10.4. found: C, 65.3; H, 6.9; N, 10.4%.

المصدر