تفاعل #2325

معادلة التفاعل

Charcoal

product

4-acetylamino-1-benzylpiperidine

hydrochloric acid

hydrogen

→

4-acetylaminopiperidine hydrochloride

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىhydrogenated at room temperature
2. 2
   ترشيحthen filtered through diatomaceous earth
3. 3
   أخرىthe filtrate evaporated to dryness

الإجراء التجريبي

10% w/w Palladium on charcoal (1.5 g) was added to a solution of the product from step (i) (10.0 g), 1 molar hydrochloric acid (21.5 ml) and methanol (150 ml) and the mixture hydrogenated at room temperature and pressure until the theoretical amount of hydrogen had been taken up. Charcoal was added, the mixture stirred for 1 hour then filtered through diatomaceous earth and the filtrate evaporated to dryness giving 4-acetylaminopiperidine hydrochloride, 8.64 g, as a sticky foam: NMR (CDCl3 +d6DMSO). δ 9,72(1H,b), 9.02(1H,b), 7.40(1H,bd), 3.87(1H,m), 3.30(2H,m), 2.81(2H,m), 1.86(4H,m), 1.80(3H,s); m/e 143 (M+H)+.

المصدر