تفاعل #2324041

معادلة التفاعل

2-Aminomethyl-5-methoxy-pyrimidin-4-ol

6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione

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title compound

المردود 34.6%

4-{[(4-Hydroxy-5-methoxy-pyrimidin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione

المردود 34.6%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe N,N-dimethylformamide is then removed
2. 2
   أخرىresidue purified

الإجراء التجريبي

2-Aminomethyl-5-methoxy-pyrimidin-4-ol (10 mg, 0.064 mmol) and 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (50 mg, 0.15 mmol) in N,N-dimethylformamide (3 mL) is stirred at room temperature for 1 hour. The N,N-dimethylformamide is then removed and residue purified to provide the title compound (10 mg, 34%). MS (ESI): 453 (M+1)+1.

المصدر