تفاعل #2324

معادلة التفاعل

Water

Acetyl chloride

4-amino1-benzylpiperidine

triethylamine

→

4-acetylamino-1-benzylpiperidine

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىto reach ambient temperature
2. 2
   أخرىthe organic phase separated
3. 3
   أخرىdried
4. 4
   أخرى(MgSO4), and removal of the solvent
5. 5
   أخرىby evaporation

الإجراء التجريبي

Acetyl chloride (3.95 ml) was added dropwise to a stirred solution of 4-amino1-benzylpiperidine (10.0 g) and triethylamine (7.7 ml) in dry dichloromethane (100 ml) at 4° C. The mixture was allowed to reach ambient temperature and stirred for 16 hours. Water was then added, the organic phase separated and dried (MgSO4), and removal of the solvent by evaporation gave 4-acetylamino-1-benzylpiperidine, 10.23 g, as a light brown solid which was used without further purification: NMR (CDCl3) δ 7.29(5H,m), 5.29(1H,b), 3.79(1H,m), 3.49(2H,s), 2.80(2H,dm), 2.12(2H,dt), 1.95(3H,s), 191(2H,dm), 1.46(2H,dq); m/e 233 (M+H)+.

المصدر