تفاعل #2320113

معادلة التفاعل

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine-4-ol

trifluoroacetic acid

→

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 24 hours
2. 2
   أخرىThe phases were separated
3. 3
   غسيلthe organic phase was washed with two portions of 10%-Na2CO3
4. 4
   تجفيفdried (MgSO4)
5. 5
   ترشيحfiltered
6. 6
   أخرىevaporated to dryness

الإجراء التجريبي

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine-4-ol (1.5 g) was dissolved trifluoroacetic acid (35 ml) and refluxed for 24 hours and then CH2Cl2 (200 ml) was added. The phases were separated and then the organic phase was washed with two portions of 10%-Na2CO3, dried (MgSO4), filtered and evaporated to dryness. Yield 1.5 g. MS m/z (relative intensity, 70 eV) 351 (M+, 27), 172 (9), 92 (11), 91 (bp), 65 (21).

المصدر